Sophoricoside attenuates autoimmune‑mediated liver injury through the regulation of oxidative stress and the NF‑κB signaling pathway
نویسندگان
چکیده
The prevalence of autoimmune hepatitis (AIH) is increasing, yet specific pharmacotherapies remain to be explored. present study aimed investigate the effects sophoricoside (SOP), a bioactive component medical herbs, on AIH and elucidate underlying mechanisms. Bioinformatic approaches were used predict potential targets regulatory mechanisms SOP AIH. evaluated by determining expression levels inflammatory cytokines, histological liver injury hepatic fibrosis in an improved chronic cytochrome P450 2D6 (CYP2D6)‑AIH mouse model concanavalin‑A (ConA)‑induced acute immune‑mediated injury. antioxidant activity was detected in vivo in vitro experiments. selected signal targeted further confirmed using western blot analysis immunofluorescence staining. results bioinformatic revealed that related oxidative stress NF‑κB gene set. transcription factor family key player controls both innate adaptive immunity. activation signaling pathway often associated with disorders. In animal experiments, attenuated CYP2D6/ConA‑induced AIH, as evidenced significant reduction enzymes serum, cytokine lesions liver. response also significantly inhibited SOP, decrease malondialdehyde, elevations total capacity glutathione peroxidase levels. experiments reduced enhanced nuclear translocation phosphorylated p65 livers mice lipopolysaccharide‑stimulated AML12 cells. On whole, demonstrates protective role which may mediated limiting hepatocytes.
منابع مشابه
Trichostatin A attenuates oxidative stress-mediated myocardial injury through the FoxO3a signaling pathway
Trichostatin A (TSA), a histone deacetylase inhibitor, is widely used as an anticancer drug. Recently, TSA has been shown to exert a protective effect on ischemia/reperfusion (I/R) injury; however, the underlying mechanisms remain unclear. Forkhead box O3a (FoxO3a), a unique FoxO family member, has been shown to attenuate myocardial injury by increasing resistance to oxidative stress in mice. T...
متن کاملGlutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice
Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...
متن کاملKaempferol Attenuates Cardiac Hypertrophy via Regulation of ASK1/MAPK Signaling Pathway and Oxidative Stress.
Kaempferol has been demonstrated to provide benefits for the treatment of atherosclerosis, coronary heart disease, hyperlipidemia, and diabetes through its antioxidant and anti-inflammatory properties. However, its role in cardiac hypertrophy remains to be elucidated. The aim of our study was to investigate the effects of kaempferol on cardiac hypertrophy and the underlying mechanism. Mice subj...
متن کاملElectroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain
Objective(s): Fibromyalgia (FM) is a central nervous system disorder characterized by widespread mechanical hyperalgesia due to unknown mechanisms. Several inflammatory mediators, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor necrosis factor, are increased in the serum of FM patients. Although medications including pregabalin, duloxetine, and milnacipran are used...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2023
ISSN: ['1107-3756', '1791-244X']
DOI: https://doi.org/10.3892/ijmm.2023.5281